Fredonia (Biscoe) is a city[4] in Prairie County, Arkansas, United States.

The settlers backed by white Southerners from the U.S. wanted to establish an independent Native nation but the dream ended in an armed conflict by Mexican troops.

The town has an African-American majority from a history of slavery in the antebellum era and agricultural labor afterwards.

According to the United States Census Bureau, the town has a total area of 2.4 km2 (0.93 sq mi), all land.

The racial makeup of the town was 58.19% Black or African American, 0.42% from two or more races, and 41.39% White.