Khasawneh was an ambassador of Jordan to Egypt, France, Kenya, Ethiopia, African Union, League of Arab States,[2] and to UNESCO.

He served as the adviser to King Abdullah II for Communication and Coordination at The Royal Hashemite Court between April 2019 and August 2020.

[18] Upon his appointment as Prime Minister on 8 October 2020, King Abdullah II instructed him to improve the capabilities of the state in the COVID-19 pandemic in Jordan.

[20] Al-Khasawneh stated he wanted to overhaul the Jordan economy, while focusing on developing a public safety net and planning a realistic government budget.

[21] Al-Khasawneh declared in a speech to the Jordan parliament in January 2021 that Jordan would receive 1 million doses of COVID-19 vaccine from BioNTech/Pfizer and 2 million doses from the COVAX initiative led by the Global Alliance for Vaccines and Immunization (GAVI), the World Health Organization (WHO), and the Coalition for Epidemic Preparedness Innovations (CEPI).