On 11 November 1962, a 22-year-old man who joined the Syrian (St. Mary's) Monastery in Wadi Natroun in Egypt was ordained as a monk, with the name "Missael" after St. Missael the Anchorite, where Pope Shenouda III (117th Pope from 1971 – 2012) and Metropolitan Pachomious (the Patriarchal locum tennis in 2012) were fellow monks.

It is known that Fr Missael served for a period of four years as secretary of Pope Cyril VI.

During his time as General Bishop, Bishop Missael consecrated St. Mary & St. Antony's Coptic Orthodox Church in 1985 and established St. Mary & St. Mark's Coptic Orthodox Centre in 1989 – both in Birmingham.

This was the first diocese established by the Coptic Orthodox Patriarchate in all the lands of immigration (including Europe, America, Australia).

Bishop Missael is based at St. Mary & St. Mark's Coptic Orthodox Centre in Birmingham, and oversees the diocese, which has 15 churches and missions.