Currently, the Archdiocese of Hermosillo has three suffragan dioceses: Ciudad Obregón and Culiacán, and the newly created (in 2015) Nogales.

The Gospel was first preached in the territory by the celebrated Father Niza, who accompanied the daring expeditions of the first explorers and conquerors of Mexico.

The Spaniards settled at different places in this section; they evangelized the numerous tribes who lived in that region in the beginning of the seventeenth century, after having established the new See of Durango, to which all these lands were given.

In 1891 Leo XIII, by the Bull Illud in Primis, separated this See from the ecclesiastical Province of Guadalajara and made it a suffragan of the new Archdiocese of Durango.

The bishop's residence was first situated in the city of Arizpe, but owing to the uprising of the Indians it was removed to Álamos and later to Culiacán, the present capital of the State of Sinaloa.