The S.46 had a redesigned wing of longer span and a far more powerful engine.

The type was employed by Franco-Roumaine, which purchased 38 out of the 40 examples produced for use on their continental European routes.

In 1922 one of the S.46s, modified to use a more powerful 336 kW (451 hp) Lorraine 12E Courlis W-12 engine was redesignated S.86.

In 1925, the surviving 34 Franco-Roumaine aircraft were recalled to Blériot where they underwent remanufacture to incorporate various refinements.

One of these aircraft was subsequently also modified to use a more powerful 336 kW (451 hp) Lorraine 12E Courlis W-12 engine and redesignated S.116.