It is a follow-up to Chaykin's 1988–89 series Black Kiss, and like its predecessor attracted considerable controversy due to its sexual content.

After noting he was planning to follow up Black Kiss in 2010, telling Comic Book Resources "I've got the premise for the sequel, but I haven't had the opportunity or the time to do it yet.

Each pair of chapters would take place in a different era, and Chaykin hoped he would be "able to deliver material that will appall and disgust a modern generation".

1 was published in August 2012, Rich Johnston of Bleeding Cool described it as "the most explicit Image comic book to date", but noted the title being carried in Diamond Previews was a considerable change in the industry compared to the publication's handling of the first series.

[9] In May 2013, Black Kiss 2 was one of 56 titles removed from the iOS version of online comic sales platform ComiXology after pressure from Apple.

[10] Chaykin, who mistakenly believed ComiXology was a blog review platform, was typically bullish about the controversy, stating "I’m long past giving a shit what people think about me and my work.

Ilona has taken on the name of Blanche DeWolfe, and is performing topless cabaret at nightclubs with Dagmar, where they pose as sisters and have sex with both Nazis and French collaborators before killing them.

Having faked her death, she resurfaces in 1957 in Vanaheim, a town in Orange County, California, now using the identity Beverly Grove and murdering men while she searches for another Dagmar.

As a result, Danny falls under her control and arranges for Detective Fabrikant to kill Dagmar, visiting Beverly to take her place as thrall.

The blonde empties an urn on herself and is explosively reborn as Beverly; Cass leaves and grabs Rosemary, and the pair flee from Vegas.

[19] Joe Glass of Bleeding Cool criticised Chaykin's attitude towards transexuals various works, noting Black Kiss 2 "again features pre-op transgender characters in very sexualised scenarios".