The trilogy was directed by Stephen Norrington, Guillermo del Toro and David S. Goyer, the latter of whom also wrote the films and created the television series.

Blade becomes aware of this and investigates further, uncovering a plot to raise the blood god La Magra, something he must stop at all costs.

Now their quickly expanding population threatens the existence of vampires, and soon there won't be enough humans in the world to satisfy their bloodlust.

In the final installment of the series, the vampires succeed in framing Blade for the killing of a human (who was in fact a familiar being used as bait).

Blade, Hannibal King, and Abigail Whistler go after Danica Talos, who has succeeded in locating and resurrecting Drake, also known as Dracula, the first vampire and by far the most powerful.

In order to stop him, Blade has to release a virus that will wipe out all vampires, but being a dhampir, he must face the possibility of also dying as a result.