Blepharidium is a monotypic genus of flowering plants in the family Rubiaceae.

Blepharidium guatemalense, which is native to Guatemala, Honduras and southern Mexico (Chiapas, Campeche, Tabasco).

[4] The name is derived from the Ancient Greek words blepharitis or blepharidos, meaning "on an eyelid".

The similar term, blepharis means "an eyelash".

[5] A cladistic analysis of morphological characters found Blepharidium to be closely related to Cosmibuena, Balmea, and Hillia,[6] but a molecular phylogenetic study placed it closer to Rondeletia.