Bletsoe is a village and civil parish in Bedfordshire, England.

The village has a small park, the former site of Bletsoe Castle and a church.

Nearby places are Sharnbrook, Milton Ernest, Riseley, Thurleigh, Odell, Souldrop, and Swineshead.

The small hamlet of Bourne End borders Bletsoe and is part of the civil parish.

In 1086, Bletsoe parish was within the ancient hundred of Buckelowe.