The club was established as a home for blues musicians, although today it books predominantly indie rock acts and local groups.

Tom Isaia and Jerry DelGiudice created it as a European-influenced cafe, complete with espresso/cappuccino, a unique and varied food menu, including home made soups, Italian biscotti, crostini, a full wine and beer list, and top-notch blues entertainment.

They doubled the club's space by renovating the rear portion of the building, opening the 8-Ball Saloon on the lower level and moving the stage to the more spacious main floor.

The expansion made the venue more conducive to crowd-heavy rock shows and has hosted acts such as Tally Hall, Joan Baez, Bo Diddley, George Thorogood, 10,000 Maniacs, Sonic Youth, Soul Asylum, Bob Mould, Soundgarden, The Smashing Pumpkins, The Velvet Beat, Pearl Jam, Nirvana, No Doubt, Dave Matthews Band, Tool, Jewel, Godsmack, Papa Roach, and John Mayer.

[3][1] Since then, the Blind Pig has attracted a steady stream of up-and-coming acts, hosting shows almost every night all year round.