From 2002 to 2005 Reynolds Brown served as a national Robert Wood Johnson Foundation fellow in the area of Urban Health Initiatives providing an intensive learning experience in planning and implementing strategic and innovative policy system changes for children, youth and families.

[4] From 1982 to 1986, Reynolds Brown served as a committee person for the Third Division of Philadelphia's 24th Ward, beginning her career in politics.

Brown's campaign manager was later accused of using $100,000 of political donations for personal uses and eventually found guilty of wire fraud.

Per the Philadelphia Home Rule Charter, a candidate for City Council At-Large must place 5th or higher in their party primary held in May.

Reynolds Brown's core issues were women, children, education, arts and culture, and small business development.

[10] Women on Boards: Advancing female entrepreneurship opportunities and leveling the playing field on business and governmental contracts.

[16] Littering Bill: Increased the availability of trash and recycling bins by placing them within 10 feet of any business selling food.

[21] Hate Crime Bill: Added a new chapter to the Philadelphia Code that provides additional penalties for criminal conduct motivated by hatred regarding sexual orientation, gender identity, and disabilities.

Through this program, Reynolds Brown has honored hundreds of successful business and professional women, working mothers, and Philadelphia's "Next Generation of Female Leaders: Rising Stars".

[39] In 2010, Reynolds Brown filmed an It Gets Better video as part of a national campaign to combat bullying-related suicide by LGBT youth.