The film involves the painter Saint Simon (John Phillip Law) who loses his sanity after the death of his wife.

Along with his butler Hermann (Gordon Mitchell), they meet a young pianist named Sybille (Brigitte Christiensen) who resembles his dead wife home to their castle.

After Saint Simon discovers that blood from a murder victim re-inspires him artistically, he orders Hermann to seek out more women for him while Sybille is held captive in the castle.

Blood Delirium was director Sergio Bergonzelli's first attempt at a gothic horror film in his three-decade career which spanned working in Italy, France, Turkey, Spain and Greece.

[5] Robert Firsching of AllMovie opined that Blood Delirium was a "ridiculous horror film" that was " Absolute trash, this one is for completists and masochists only.