Blood of Heroes is set in its own fictional world, rather than the DC universe.

It is a point-based system starting with a base of 450 Hero Points to create a character, which allows the player to design a character typical to sidekick power levels.

The actual world included with the game is a 1990s style superhero world with a heavy influence of occult and magical beings, which accounts for the much more detailed magic system included in the game.

[1]: 171  The original Blood of Heroes was criticized for using poor artwork.

[1]: 171  A second edition, titled "Blood of Heroes: Special Edition" (pictured above) was printed in 2000 and featured expanded rules and new artwork, including cover art by Dave Dorman.