This species is relatively smaller in size than the other Spilocuscus cuscuses and has distinct pale blue eyes.

The blue-eyed spotted cuscus can be found on several of the islands in the Cenderawasih Bay in West Papua of Indonesia.

Due to the rugged terrain common on the Supiori Island, it is better insulated from human foot traffic and allows for a more flourishing population than that on Biak.

The major threats to the blue-eyed spotted cuscus include habitat loss, hunting, and collection for the exotic pet trade by locals.

Due to its rarity, the blue-eyed spotted cuscus was only scientifically described in 2004 and was deemed critically endangered by the IUCN in 2015.