It is an adaptation of the Franco-Belgian comic book series Blueberry, illustrated by Jean Giraud (better known as Moebius) and scripted by Jean-Michel Charlier, but the film has little in common with the source material.

The film starred Vincent Cassel as the title character along with Michael Madsen, Juliette Lewis, Djimon Hounsou, Eddie Izzard, Temuera Morrison, Tchéky Karyo, Kestenbetsa, and Ernest Borgnine.

Since the character of Blueberry remains obscure in the States, the film was released on DVD in America in November 2004 under the title Renegade and marketed very much as a conventional Western.

Marshal Mike Donovan (Vincent Cassel) (referred to as Broken Nose by the aboriginal tribe; unlike the comic his nickname is not Blueberry) has dark memories of the death of his first love.

The evil actions of Blount, a "white sorcerer" lead him to confront the villain in the Sacred Mountains, and, through shamanic rites involving an entheogenic brew, conquer his fears and uncover a suppressed memory he would much rather deny.

Peyote is shown growing in the sacred areas throughout the film, and the buttons are prominently displayed at the end, although the viewer cannot be sure what Runi offers to the Marshal either time.