BmKAEP

[1] BmKAEP is one of the components of Mesobuthus martensii's venom,[2] a well-known scorpion belonging to the family Buthidae, which is found distributed throughout Eastern Asia and China.

[3] Despite its high homology with other depressant toxins, BmKAEP differs from them at residues 6, 7 and 39, which is thought to be important in determining its unique function.

[4] 01 mklflllvis asmlidglvn adgyirgsng 31 ckvsclwgne gcnkeckafg ayygycwtwg 61 lacwceglpd dktwksesnt cggkk Because of its sequence homology with other β-toxins, BmKAEP is predicted to bind to site 4 (S4) of voltage-gated Na+ channels, at domains I, III and IV.

[2] BmK venom induces a transient phase of contraction followed by a slow progressive flaccid paralysis in insect larvae.

[9] Mesobuthus martensii, especially its tail, has been used in Chinese traditional medicine to treat several neuronal diseases, such as several types of paralysis, apoplexy and epilepsy.