Božidar Špišić (September 6, 1879 in Sisak - August 31, 1957 in Zagreb) was a Croatian orthopedist and rector of the University of Zagreb.

In 1908, Špišić formed the first orthopedic bureau in Croatia, which is seen as the founding of orthopedics in the country.

[1] Špišić formed the orthopedic clinic in Zagreb in 1930.

[4] The Croatian Academy of Sciences and Arts held a symposium on Špišić in 2005.

[5] In 2008, Špišić's native city of Sisak decided to name a street in his honour to mark the 100th anniversary of orthopedics in Croatia.