Complications ensue when Ace Comics head Harlan Stone (John Cygan) insists Mad-Dog should be a bloodthirsty vigilante rather than the hero Bob originally created.

In the final episode of the first season, AmCanTranConComCo is sold to a millionaire who hates comic books, and the entire Mad-Dog staff, including Bob, is fired.

At work, Bob has to deal with the more eccentric staff members: klutzy gofer Albie Lutz (Andrew Bilgore); spaced-out cartoon inker Chad Pfefferle (Timothy Fall); and curmudgeonly artist Iris Frankel (Ruth Kobart).

Eventually, Bob also hires Trisha onto the Mad-Dog staff, where Chad develops a crush on her; she also moves into an apartment with her best friend, Kathy (Lisa Kudrow), where Albie also joins them temporarily.

Others working at the company are the bookkeeper Chris Szelinski (Megan Cavanagh) and Whitey van der Bunt (Eric Allan Kramer), a member of the production team who adores Bob.

One character was heard but not seen – Mr. Terhorst (voice of Michael Cumpsty), the president of AmCanTranConComCo who communicates with all his employees anywhere that fiber optics can be installed.

The season one episode "You Can't Win" played upon the series' comic book connection by guest starring comic book artists Bob Kane, Jack Kirby, Mell Lazarus, Jim Lee, Marc Silvestri, Mel Keefer, Paul Power, Art Thibert and Sergio Aragones (co-creator of Groo with "Bob" scripter Mark Evanier.)

[31] The series' theme music was originally a full orchestral piece featuring a heavy horns and woodwinds sound, an arrangement very much in style of the Superman and Batman movies.

[citation needed] The opening sequence that accompanied it featured Bob McKay at his artist's desk drawing, inking, then coloring a Mad-Dog comic as the credits appeared.

When the season ended, the other three Friday night sitcoms were cancelled and Bob underwent a retooling, saved from the axe by a relocation to Mondays and a subsequent ratings boost.