He came to prominence in the late 1970s as the rhythm guitarist and keyboardist of the new wave band Devo, which released a Top 20 hit in 1980 with the single "Whip It".

He was born with the last name Pizzute because his father had legally changed his name from Robert Edward Casale to that of his foster parents.

In Devo concerts, Casale played the lead and rhythm guitar and keyboards while also working with MIDI sampling.

[8] As Devo's mainstream popularity waned during the mid-1980s and its various members began working on side projects, Casale transitioned to audio engineering and record production.

He engineered and mixed Mark Mothersbaugh's debut solo studio album Muzik for Insomniaks in 1985, which was later expanded and released as two CDs in 1988.

In 1986, Casale produced and engineered Martini Ranch's debut EP "How Can the Labouring Man Find Time for Self-Culture?"

In 1989, Bob Casale and other members of Devo were involved in the project Visiting Kids, releasing a self-titled EP on the New Rose label in 1990.

[11] On February 17, 2014, Casale died at the age of 61, in Los Angeles, California, due to heart failure.

Devo toured the U.S. and Canada in June and July 2014, playing ten dates consisting of their "experimental music" composed and recorded from 1974 to 1978.