He came to prominence in the late 1970s as co-founder, co-lead vocalist and bass player of the new wave band Devo, which released a top 20 hit in 1980 with the single "Whip It".

Casale has also directed music videos for other recording artists, including the Cars ("Touch and Go", "Panorama"), Rush ("Mystic Rhythms", "Superconductor"), A Perfect Circle ("Imagine"), Foo Fighters ("I'll Stick Around"), Soundgarden ("Blow Up the Outside World") and Silverchair ("Freak", "Cemetery"), among others.

He was born with the last name Pizzute because his father, Bob, had legally changed his name (his birth name having been Robert Edward Casale) to that of his foster parents.

He has said that David Bowie's 1974 album Diamond Dogs and its subsequent tour inspired him to "raise the bar" for his work with Devo, stating, "I had seen what it takes to combine theater, concept and music in a three-stage rocket to mind-blowing effect.

[12] On October 14, 1978, Devo appeared on American variety show Saturday Night Live to promote their debut album, Q: Are We Not Men?

[16] The band's sixth studio album, Shout (1984), continued in this vein and was received poorly, which caused Warner Bros. to buy out the remainder of Devo's contract.

Their first project was a soundtrack for the horror film Slaughterhouse Rock (1988), starring Toni Basil, after which they released the albums Total Devo (1988) and Smooth Noodle Maps (1990), on Enigma.

Following the split, Casale began a career as a director of music videos and commercials, working with bands including Rush, Soundgarden, Silverchair and the Foo Fighters.

"[21] In an April 2007 interview, Gerald Casale mentioned a tentative project for a biographical film about Devo's early days.

[29] Devo was scheduled to perform at Moogfest, but Bob Mothersbaugh severely injured his hand three days prior, and the band was forced to cancel.

Mark Mothersbaugh and Gerald Casale collaborated with Austin, Texas, band The Octopus Project to perform "Girl U Want" and "Beautiful World" at the event instead.

[30] In an interview on March 3, 2011, Casale stated that he was "working on a script for a... Devo musical" that would be aimed towards a live Broadway production.

[35] In April 2020, Casale participated in a long-form interview with the Conan Neutron's Protonic Reversal podcast, discussing many subjects related to the band and more.

The organizers stated, "As a primary force behind Devo's creative vision, Jerry Casale is also responsible for designing the band's visually striking concert stage shows and Dadaist costumes, including their signature red 'Energy Dome' hats.

[40] Casale directed several television commercials, including ads for Diet Coke and Honda Scooters featuring Devo, as well as for Coco's restaurants,[41] and Miller Lite.

[42] While Jihad Jerry never toured, the theatrical character appeared with Devo at several shows in 2006, as well as on the Fox News program Red Eye.

[44] Later Casale donned the Jihad Jerry turban for a performance with UK-based DJ and producer Adam Freeland at the South by Southwest music festival in 2009.

[46] In 2014, Casale made a cameo appearance in a 1980s themed Delta Air Lines in-flight safety video, portraying a passenger who puts his "carry on" item (a Devo energy dome) under the seat in front of him in order to prepare for takeoff.

Among the most distinctive is a teardrop shaped bass, actually a Gibson Ripper with its horns sawed off and a thick arm padding added to the top side, as seen in videos for "(I Can't Get No) Satisfaction" and "Come Back Jonee".

[53] Casale bought the historic Josef Kun House in 2007 and spent seven years in meticulous restoration with the help of preservationist James Rega.

After joking that he and Napp were "the Twin Towers of love", a friend who was in charge of the cake fashioned a 9/11-themed reception without their knowledge, featuring a cake baked in the shape of the Twin Towers, box cutters as party favors and table place setting cards featuring images of box cutters with "Gerald & Krista" engraved on them.

After TMZ ran a story about the event on September 14 and published photos, Casale received significant backlash from the media and online.

Apologizing to anyone who was offended, Casale called the reception a "surprise" and a "set-up", explaining that his friend "thought it was some sort of transgressive sick humor and the problem is, it's not funny.

[59] In a 2022 interview with Spin, Casale stated that his five favorite albums were Bob Dylan's Greatest Hits (1967), The Velvet Underground & Nico (1967), the Jimi Hendrix Experience's Electric Ladyland (1968), David Bowie's Diamond Dogs (1974) and the Chemical Brothers' Dig Your Own Hole (1997).