DuBose was born in Fort Lauderdale and attended the University of Florida, graduating with a degree in economics and then working as a self-employed insurance agent.

[1] In 2009, he ran for the Fort Lauderdale City Commission from District III, and came in first in the municipal primary election, receiving 49% of the vote to Pamela Adams's 31%, Nadine Hankerson's 12%, and Magdalene J. Lewis's 8%.

In 2014, incumbent state representative Perry E. Thurston, Jr. was unable to seek re-election due to term limits, so DuBose ran to succeed him.

After a contentious primary, DuBose won his final term in the Florida House of Representatives with 69% of the vote to Manley's 31%.

[6][7] On April 20, Dubose declared he was running for Congress in the special election after incumbent Alcee Hastings died from pancreatic cancer.