Engram played college football for the Penn State Nittany Lions and was selected by the Chicago Bears in the second round of the 1996 NFL draft.

He garnered All-American honors and won the inaugual Biletnikoff Award, recognizing the season's outstanding college football receiver.

[3] He also racked up 786 career punt return yards for the Nittany Lions, ranking him second in school history.

Despite being a starter in only 67 of the 109 games he played with Seattle, Engram ranks fifth in franchise history in receptions (399) and fourth in receiving yards (4,859).

Engram signed with the Cleveland Browns in the 2010 preseason, but failed to make the roster and was released before the regular season began.

[9] The same day, Engram announced his retirement, he also accepted a job as an offensive assistant coach for the San Francisco 49ers.

[11][17][18] In 2006, Engram was diagnosed with Graves-Basedow disease, which caused him to miss playing time during the season.