Together they have written, directed and produced several comedy films including Dumb and Dumber, There's Something About Mary, Kingpin, Shallow Hal, Me, Myself & Irene and Stuck on You, and Fever Pitch.

Dumb and Dumber, 1994 Farrelly co-directed this iconic comedy, in which a business woman, played by Lauren Holly, accidentally leaves her briefcase at an airport terminal.

[16] Farrelly co-directed this slapstick dark comedy about a state trooper in Rhode Island, played by Jim Carrey, whose years of suppressed rage results in a psychotic break and split personality.

[19] The Farrelly brothers wrote, directed and produced romantic comedy Shallow Hal, a film about a superficial man who falls in love with a 300-pound woman after being hypnotized into only seeing a person's inner beauty.

[20] Written and directed by the Farrelly brothers, Stuck on You is a comedy film starring Matt Damon, Greg Kinnear, Eva Mendes and Meryl Streep about conjoined twins who move to Hollywood so one can pursue a career as an actor.

[21] In 2005, Farrelly co-directed Fever Pitch, a romantic comedy starring Drew Barrymore and Jimmy Fallon about a schoolteacher and Red Sox fanatic who falls in love with a business consultant.

[35] In 2020, the Farrelly brothers received the Morton E. Ruderman Award for their sensitive and inclusive depictions of people with differing abilities in Champions.