From 2001 to 2009, Lee was a cast member on MADtv, and he co-starred in the ABC single-camera sitcom series Splitting Up Together alongside Jenna Fischer and Oliver Hudson between 2018 and 2019.

He had a guest appearance as the cynical, burned-out Dr. Kang on FX on Hulu's TV comedy series Reservation Dogs.

[10] Within a year of doing regular comedy sets, he received offers to open for both Pauly Shore and Carlos Mencia.

[6][10][8] During a podcast interview conducted by fellow actor and comedian Joe Rogan on February 1, 2011, Lee stated that during the first few years he did stand-up, his parents barely spoke to him.

He has stated that he dreaded playing the characters Bae Sung and Connie Chung, as well as the "Average Asian" skits.

[19] The hosts discuss events from their lives and news topics from popular culture, often revolving around Asian American issues related to the entertainment industry, adolescence, sexuality, ethnicity, racism, and politics.

[citation needed] Prior to the creation of TigerBelly, Lee and Erik Griffin pitched a podcast to All Things Comedy but never developed the show.

[25][7] He got sober after MADtv producer Lauren Dombrowski fought for him after he was fired from the show a second time, a story which Lee discusses in his appearance on the pilot episode of Comedy Central's TV series This Is Not Happening.

[26] On TigerBelly episode 224, Lee admitted to guest Theo Von that he had relapsed after his father's death in August 2019 from Parkinson's disease.

Lee is an avid fan of video games, including FIFA, Stardew Valley, The Elder Scrolls, Red Dead Redemption 2, and The Witcher series.