[5][3] In June 2022, Kenewendo was appointed as Special Advisor and Africa Director to the United Nations Climate Change High-Level Champions.

On 4 April 2018, the new incoming president, Mokgweetsi Masisi, appointed Kenewendo as the new Minister of Investment, Trade and Industry.

[9] In her capacity as minister, Kenewendo was appointed by United Nations Secretary General António Guterres in 2018 to the High-level Panel on Digital Cooperation, co-chaired by Melinda Gates and Jack Ma.

[10] As the Minister of Investment, Trade and Industry in Botswana, she implemented reforms to significantly improve the ease of doing business, open up both domestic and international markets, and position the country to succeed in the global value chains as well as the digital economy.

2024 set a different tone for Kenewendo and Botswana as she was specially elected to be a Member of Parliament under the new administration, sworn in as minister of Minerals and Energy.