The Bolshaya Laba (Russian: Большая Лаба; Adyghe: Лабэшхуэ, Labešxwe, [laːbaʃxwa]), or Great Laba, is a 133-kilometer (83 mi) river in the Karachay-Cherkess Republic, Russia.

Other left tributaries of the river include Sancharo, Makera, Mamkhurts, Damkhurts, and Zakan, which originates from the glaciers of the Main Caucasian Range.

Several villages and settlements are located along the banks of Bolshaya Laba, including Pkhiya, Zagedan, Damkhurts, Rozhkao, Psemyon, Kurdzhinovo, Ershov, Podskalnoye, Predgornoye, and the abolished village of Akhmet-Kaya, which are located in Karachay-Cherkessia.

In the Krasnodar Territory, the river passes through the settlements of Akhmetovskaya, Chernorechenskaya, and Gofitskoye.

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