It flows into the Pacific Ocean at the town Ust-Kamchatsk, on the east coast of Kamchatka.

[1] The river is rich with salmon, millions of which spawn yearly and which once supported the settlements of the native Itelmen.

[2] Like most of its namesake peninsula, the basin of the Kamchatka River has at low altitudes a subarctic climate (Köppen Dfc) with short, cool-to-comfortable summers and freezing, snowy winters.

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