Bolshoy Cheremshan (Russian: Большой Черемшан, literally Greater Cheremshan, Tatar: Олы Чирмешән) is a river in Russia, a left tributary of the Volga between the Kama and Samara.

The main inflows are the Bolshaya Sulcha and Maly Cheremshan.

The maximal discharge is 1,660 cubic metres per second (59,000 cu ft/s) (1979), and the minimal mineralization is 600-800 mg/l.

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