Bone Brothers 2 is an album the record label put out.

It was released via Real Talk Entertainment on May 8, 2007, the same day as Bone Thugs-n-Harmony's Strength & Loyalty.

Recording sessions took place at the White House with Black Trim.

Production was handled by Big Hollis, Vince V., Preach and Derrick "Sac" Johnson, who also served as executive producer.

Albums purchased at Best Buy include three bonus Bizzy Bone tracks.