He made a career-high six interceptions (including two in his first game, against Hall of Famer George Blanda), and was named to the AFL All-Rookie team.
Edgerson's college background as a sprinter and long jumper served him well in the demanding role of man-to-man pass coverage[citation needed].
The Bills beat the San Diego Chargers in 1964 and again in 1965, when Edgerson was selected as an American Football League All-Star.
He also forced and returned a fumble for the deciding score in a 1969 game against the Cincinnati Bengals, played in blizzard conditions.
Edgerson retired to Buffalo, where he has been involved in numerous charitable endeavors through the Bills Alumni, and was the 1993 recipient of the Ralph C. Wilson Award.