George Thomas Saimes (September 1, 1941 – March 8, 2013) was an American professional football player who was a defensive back for the Buffalo Bills of the American Football League (AFL).

He played college football as a fullback for the Michigan State Spartans.

In 1964, he had a career-high six interceptions and earned the first of his five American Football League All-Star Game appearances.

He achieved All-American Football League honors five times, and is a member of the American Football League All-Time Team, the Buffalo Bills' Wall of Fame, and the Greater Buffalo Sports Hall of Fame.

Saimes went on to be a professional football scout with the Blesto V Combine, the Tampa Bay Buccaneers, the Washington Redskins, and the Houston Texans.