Bootle entered Lloyd's Register in 1805 with J. Sillars, master, Kitchen, owner, and trade Liverpool–Africa.

[3] First slave voyage: Sillars sailed from Liverpool on 16 November, bound for Africa.

[1] Second slave voyage: Sillars sailed from Liverpool on 11 March 1807 and Bootle arrived at Kingston on 1 September.

[3] On 5 May 1809 Lloyd's List reported that Bootle, Ferguson, master, had arrived at Liverpool.

An American privateer had captured Two Brothers as she was sailing from Baltimore to Cadiz and had taken off her master and papers[7] A hurricane wrecked Bootle at Bridgetown, Barbados, on 23 July 1813.

[8] Bootle, Ford, master, was lost though a portion of her cargo, one hogshead and two tierces of sugar (out of 140), was saved.