HMS San Domingo was a 74-gun third-rate ship of the line of the Royal Navy, launched on 3 March 1809 at Woolwich.

On 14 August 1812 Admiral Sir John Borlase Warren, sailed to Halifax, Nova Scotia, on San Domingo}, together with Poictiers, Sophie, Magnet, and Mackerel.

[3] On 13 April 1813, Sir John Borlase Warren's squadron, consisting of his flagship, San Domingo, and Marlborough, Maidstone, Statira, Fantome, Mohawk, and Highflyer pursued four schooners into the Rappahannock.

Of the three Baltimore schooners, the Racer became Shelburne; Dolphin retained her name; lastly, it is not clear what became of Arab.

San Domingo was driven ashore at Halifax, Nova Scotia, British North America, during a gale on 12 November 1813.