Heading east, the highway enters and passes through the Franklin Mountains State Park and the Fort Bliss Castner Range before leaving at Northeast El Paso, where it meets US 54.

The section through Franklin Mountains State Park includes many road cuts which expose outcrops of Precambrian rocks, which are some of the oldest in Texas.

After leaving Fort Bliss, the highway passes through Southeast El Paso, heading south through residential neighborhoods, before curving southwest to meet I-10 at a stack interchange.

After meeting the El Paso Ysleta Port of Entry, the highway curves northwest, following the Mexican border along the Rio Grande.

Heading into downtown, the highway intersects US 54 at an interchange, passing unter the El Paso BOTA Port of Entry.

The Texas Department of Transportation announced plans to add toll lanes to the Border Highway portion of Loop 375 between Downtown El Paso and the Ysleta–Zaragoza International Bridge.