Borgo Tossignano borders the following municipalities: Casalfiumanese, Casola Valsenio, Fontanelice, Imola, Riolo Terme.

During medieval times, the area was a fortified centre named Castrum Thausignanum (or Tauxignano), documented in 873.

Around that time, there was a Pieve dedicated to the Assumption of Mary, whose archpriest was the first vicar general of the Santerno valley.

The area was then abandoned by those who still resided e eventually settled at the bottom of the valley, creating Borgo.

Bologna then governed the area between 1198 and the early 1300s, reconstructing the castle in 1264 following a victory over Frederick II.