[2][1] Lojkine was born in Paris and studied at the École normale supérieure.

[1] Prior to his film career, Lojkine taught philosophy at Aix-Marseille University.

His first film projects were documentaries inspired by his time in Vietnam[2] Lojkine's narrative feature debut, Hope, screened at the Critics' Week section of the 2014 Cannes Film Festival.

[3] His second narrative feature, Camille, won the Audience Award at the 2019 Locarno Film Festival.

[4] In 2024, Lojkine's feature Souleymane's Story was selected to screen in the Un Certain Regard portion of the 77th Cannes Film Festival.