[2] In the late 3rd millennium BC a great revolt arose against Naram-Sin ruler of the Akkadian Empire.

[3][4] During the reign of Ur III ruler Ibbi-Sin (c. 2028–2004 BC) it is known that the governor of Borsippa (and nearby Babylon) was Puzur-Tutu.

From the ninth century BC, Borsippa was on the borderland south of which lay the tribal "houses" of Chaldea.

The Jewish historian, Josephus, mentions the city in relation to the war between Cyrus the Great and Nabonidus.

[12] The temple to Nabu at Borsippa was destroyed in 484 BC during the suppression of a revolt against the Achaemenid emperor, Xerxes I.

[14] In 1854, work at Borsippa was conducted under the direction of Henry Creswicke Rawlinson, with most of the actual digging done by his subordinates.

E-DIM-AN-NA, temple of the bond of heaven, built by Nebuchadrezzar for the god Sin in the court of E-zida was also excavated.

[19][20][21] Between 1980 and 2003, the Austrian team from the Leopold-Franzens-Universität Innsbruck led by Helga Piesl-Trenkwalder and Wilfred Allinger-Csollich excavated for sixteen seasons at the site.

The Austrian archeologists have determined that Nebuchadnezzar's ziggurat encased the ruins of a smaller tower from the second millennium BC.

The reconstruction under the patronage of Bel-Marduk is summarized on a cylinder in Akkadian of Antiochus I, an example of the region's remarkable cultural continuity.

[33][34][35] Since 2023, after a 20-year break in excavations, the Austrian archaeological team led by Sandra Heinsch and Walter Kuntner has resumed investigations in the ancient city of Borsippa.