BotIT6 is a neurotoxin produced by the common European scorpion, which is also known as the Buthus occitanus tunetanus.
[1][2] Structure BotIT6 consists of 62 amino-acids and has an experimentally determined molecular mass of 7260.84 Da.
[1] In artificial environments the effect of BotIT6 is less potent than it is in vivo, which might be explained by other toxic neuropeptides in the venom of the scorpion.
[1] These toxins often share many characteristics, which means they partially overlap in binding sites.
BotIT6 is known to compete with other neurotoxins, I-AaHIT and I-BotIT2, over the same binding site on the sodium channels for these toxins.
[7] In addition, within the Buthidae neurotoxin family toxins, a higher total positive charge leads to a more toxic neuropeptide .
For cockroaches for instance, the LD50 was 10 ng/100 mg. Amongst other things this toxin leads to different forms of paralysis and uncoordinated motion.