The Derry~Londonderry Line operates an hourly service between Grand Central and Derry~Londonderry, with additional trains to Coleraine at peak times.

The Derry~Londonderry Line alternates its outbound terminus every hour between Derry~Londonderry and Portrush, resulting in a two-hourly service to stations beyond Coleraine.

At one point, the cross-border Enterprise service to Dublin Connolly served Botanic, but no longer stops at the station.

[9] Belfast Metro's 7 services connect Botanic station to the City Centre, Four Winds, Laurelgrove, Braniel, and Stormont.

Additionally, the 625 Ulsterbus service also stop near the station with runs from the City Centre to Ballynahinch and Carryduff.