Bovine progressive degenerative myeloencephalopathy (BPDME), also known as weaver syndrome, is a genetic disorder of cattle, characterized by hindlimb weakness and ataxia.
It has been observed in male and female Brown Swiss cattle.
[1] BPDME is a genetic autosomal recessive disorder.
[2] The signs of BPDME are first noticed in cattle aged 5–8 months,[3] and include a weaving gait, along with weakness and lack of voluntary coordination of the muscles of the hind limbs (known as ataxia).
[2] Signs progressively worsen, and by 18–36 months of age, the animal is unable to rise.