[4] The idea of a local hospital to serve the Box Hill area first surfaced around 1937, with a 4.5-acre (1.8 ha) site in Nelson Road being acquired from the Rodgerson estate in 1945.

The Box Hill hospital provides the following services: Box Hill Hospital's new $448 million clinical services building was designed by Jackson Architecture in Association with Silver Thomas Hanley and opened by former Victorian Premier Denis Napthine in August 2014.

[8] The 10-storey Arnold St building houses the hospital's new emergency department, as well as maternity, cardiac and intensive care units.

Box Hill Hospital's new 10-storey clinical services block (known as Building A) has been designed to accommodate future growth in Melbourne's east.

[9] On 9 December 2009, the Victorian Labor government approved $407.5 million in funding for the redevelopment of the Box Hill Hospital.