The men's middleweight competition of the boxing events at the 2011 Pan American Games in Guadalajara, Mexico, was held between October 21 and 28 at the Expo Guadalajara Arena.

Middleweights were limited to those boxers weighing less than or equal to 75 kilograms.

Like all Pan American boxing events, the competition was a straight single-elimination tournament.

Both semifinal losers were awarded bronze medals, so no boxers competed again after their first loss.

Punches scored only if the white area on the front of the glove made full contact with the front of the head or torso of the opponent.