The story follows the struggles of a transgender high school boy who launches a fashion brand with his friends.

After Ryo confides in Jin about his gender dysphoria, they decide together to launch their own fashion brand, which they name "Boys Run the Riot".

[9] In North America, Kodansha USA announced the English-language release of Boys Run the Riot in November 2020.

[11][12] Kodansha USA also commissioned Keito Gaku to draw new cover art for the second, third, and fourth volumes.

[13] The first chapter of Boys Run the Riot was released for free online on March 31, 2021, in honor of International Transgender Day of Visibility.