When Akira Miyamoto learns that his older brother, Atsushi, is missing, his family begins to fall apart.

Trained by Atsushi, Akira and his friends begin the battle against Miyabi and his vampire army in order to escape the island alive.

Higanjima: Saigo no 47 Nichikan, set after the events of the original series, has Akira and his allies try to stop the invasion.

[9] A second series, titled Higanjima: Saigo no 47 Nichikan (彼岸島 最後の47日間), was serialized in Weekly Young Magazine from August 2, 2010,[6][10] to July 28, 2014.

[21] A gag comedy spin-off manga, titled Kare, Kishijima (彼、岸島), written and illustrated by Tarō Sasebo was serialized on the YanMaga Web website and the Comic Days app from October 19, 2020,[22] to December 6, 2021.

[26] Starring Shunya Shiraishi as Akira, other cast members include Ryohei Suzuki, Rio Yamashita, Megumi Sato, Rui Kurihara, Yuya Endo, Shingo Tsurumi, and Yūga Yamato.

[28] A sequel television series adapting Higanjima: Saigo no 47 Nichikan and featuring the same cast was announced in August 2014.

[30][31] Mark Schilling of The Japan Times described the vampires as "not the sensitive heartthrobs of Twilight but vicious, ravenous types who revel in terror and torture.