[1] Rubenstein's artwork is known for exploring the human form and how it might be manipulated and engineered in the future, creating hybrid characters.
[4] His paintings, photographs, and drawings reference genetic engineering and mutations, provoking discussion about the parameters and potential dissolution of self.
[3][5][6] Untitled (Girl with Puppy-Dog Eyes) (1996),[2] collection of The Metropolitan Museum of Art, New York, is a well-known piece.
[4] He has collaborated with such artists as Lucio Pozzi,[9] Sue de Beer,[10] Claude Wampler,[1][11] Bjarne Melgaard, and Sarah Michelson[4] to produce films, books, installations, and theatrical sets.
[18] He was the lead scenic artist for productions by Jonathan Demme, Spike Lee, Tom McCarthy, Jean-Marc Vallée, and Alfonso Cuarón.