A group of researchers scour the planet for Orphan's disc plates using mecha called "Antibodies" in order to revive the craft, an event that would result in the utter destruction of all lifeforms on Earth.

The protagonists Yu Isami and Hime Utsumiya must utilize a special Antibody called "Brain Powerd" to counter the Orphan plans and save humanity.

It was adapted into a manga, with art by Yukiru Sugisaki, which was serialized in Kadokawa Shoten magazine Shōnen Ace and later published in the United States in English by Tokyopop.

[1] Their agents, the "Reclaimers", pilot living organic mechas (or "Antibodies") in the army Grand Cher, and seek to retrieve Orphan's vital disc plates which are scattered across the planet.

The series begins with the teenage lead Hime Utsumiya venturing upon such a disc plate, which revives into a unique Antibody, called "Brain Powerd", with which she forms a deep connection.

Within a year, Hime joins a group wishing to counter the ideals of the Orphan researchers, stationed aboard the battleship Novis Noah.

[3] He wanted to write an interesting story for Brain Powerd in order to allow those who watched it to do so without "having a nervous breakdown" and to show fans "that there were often other things out there better than anime".

"Field of Love") was composed and arranged by Kanno, with lyrics written by Rin Iogi (a pseudonym for Tomino), and the song performed by Kokia.

[27] Following the 2012 closure of Bandai Entertainment, Sunrise announced at Otakon 2013, that Sentai Filmworks has rescued Brain Powerd, along with a handful of other former BEI titles.

[28] A manga prelude to the Brain Powerd television series, featuring the original story penned by Tomino and illustrations by Yukiru Sugisaki, was serialized monthly in the Japanese Kadokawa Shoten magazine Shōnen Ace beginning in the January 1998 issue.

[30][31] A series of three light novels written by Tomino and Akemi Mende were also published in Japan by Kadokawa Haruki Corporation: Brain Powerd Shinkai Yori Hasshi Te (ブレンパワード 深海より発して, lit.

[39] A two-volume soundtrack featuring a total of 38 background and vocal tracks from the Brain Powerd anime series was published by Victor Entertainment in Japan on August 5, 1998, and November 21, 1998.

[48][49][50][51] Jonathan Clements and Helen McCarthy of The Anime Encyclopedia summarized Brain Powerd "as if Tomino and his crew were thrown in at the deep end and told to wing it", though they found it "curiously watchable, thanks largely to Yoko Kanno's wonderful music".