Brain Quest 5 & 6 is an educational puzzle video game released for the Nintendo DS in North America on September 22, 2008.

The game was published by Electronic Arts and was developed by Planet Moon Studios.

The game was released at the same time as Brain Quest Grades 3 & 4 and is based on the curriculum-based card deck series of Brain Quest.

The player plays as an unnamed character, who has young children quiz the player trivia questions in multiple categories, such as English, science, mathematics, history, geography and a mixed mode, where all categories are combined into one quiz.

[1] This puzzle video game-related article is a stub.