The band was founded in Amsterdam by guitarist Jan Akkerman[1] , drummer Pierre van der Linden and singer Kazimir Lux (Kaz).

Their debut single was "Down Man", which established their progressive blues sound.

[2] In late 1969, soon after they released their first album, Akkerman left to join Focus, later recruiting van der Linden as well, then Brainbox bass player Cyril Havermans.

They were replaced by guitarists Herman Meyer and Rudie de Queljoe and drummer Frans Smit.

After Kaz Lux left Brainbox in 1971, popularity waned and they split up in 1972.