Bram Vandenbussche (born 1 February 1981 in Bruges) is a retired Belgian professional footballer.
Vandenbussche started his career at Cercle Brugge, where he made his first team debut on 17 December 2000, in a 1–2 home loss against Maasland.
In the 2005-2006 season, Vandenbussche startled the Belgian football competition when he failed a doping test.
The Cercle Brugge medical staff had given him an injection for this, so they also took responsibility for Vandenbussche's positive doping test.
After becoming a back-up player for Cercle, Bram Vandenbussche signed a contract for 3 years with SV Roeselare.