SC was established in 1945 as Sportgemeinde Brandenburg-West out of the former membership of Brandenburger Sport-Club 05 which, like most other organizations in the country including sports and football clubs, was disbanded by occupying Allied authorities after World War II.

Separate football leagues soon emerged in the western and Soviet-controlled areas of Germany and the Brandenburg side became part of the eastern competition.

Throughout this period they made regular appearances in the opening rounds of the FDGB-Pokal (East German Cup) with their best result being an advance to the eighth final in 1959.

The team re-emerged in second-level competition sporadically during the course of the 1970s and 1980s, and again took part in the FDGB Pokal tournament in 1983 and 1988, but otherwise largely remained out of view.

With German reunification in 1990, the club re-assumed its traditional identity to play as Branderburger SC Süd 05 and the following season was joined by the membership of Chemie Premnitz.